<p>Crossover safety study of aprepitant: 2-min injection vs 30-min infusion in cancer patients receiving emetogenic chemotherapy</p>
نویسندگان
چکیده
منابع مشابه
Comparison of the pharmacokinetics, safety and tolerability of daptomycin in healthy adult volunteers following intravenous administration by 30 min infusion or 2 min injection
OBJECTIVES Two randomized Phase I studies in separate populations of healthy adult volunteers investigated the pharmacokinetics, safety and tolerability of daptomycin (Cubicin; Novartis Pharma AG, Basel, Switzerland) administered as a 2 min intravenous (iv) injection, relative to the currently licensed 30 min iv infusion. METHODS Study 1 was an open-label, single-dose, two-period, crossover s...
متن کاملEfficacy of aprepitant in patients with advanced or recurrent lung cancer receiving moderately emetogenic chemotherapy.
AIMS AND BACKGROUND To evaluate the efficacy of a combination of aprepitant and conventional antiemetic therapy in patients with advanced or recurrent lung cancer receiving moderately emetogenic chemotherapy (MEC). METHODS Patients with advanced or recurrent lung cancer who were treated with MEC regimens at the Department of Respiratory Medicine, Fukuoka University Hospital, were included and...
متن کاملComparison of pediatric patients with status epilepticus lasting 5-29 min versus ≥30 min.
The most common thresholds for considering prolonged seizures as status epilepticus (SE) are 5 and 30 min. It is unknown whether these different thresholds (5 or 30 min) identify patient populations with different electroclinical characteristics. We compared the characteristics of patients with SE lasting 5-29 min (SE5-29) with those with SE lasting ≥30 min (SE≥30). Inclusion criteria were the ...
متن کاملEffectiveness and safety of antiemetic aprepitant in Japanese patients receiving high-dose chemotherapy prior to autologous hematopoietic stem cell transplantation.
For patients receiving high-dose chemotherapy, a 5-hydroxytryptamine 3 receptor antagonist combined with dexamethasone is a standard antiemetic therapy. Despite this prophylactic anti-emetic treatment, many patients still suffer from uncontrollable emesis. In this study, we retrospectively evaluated the antiemetic effectiveness and safety of aprepitant (a neurokinin-1 receptor antagonist) in ad...
متن کاملA Hybrid Min-min Max-min Algorithm with Improved Performance
The high cost of supercomputers and the need for large-scale computational resources has led to the development of network of computational resources known as Grid. To better use tremendous capabilities of this large scale distributed system, effective and efficient scheduling algorithms are needed. Many such algorithms have been designed and implemented. We introduce a new scheduling algorithm...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2019
ISSN: 1178-6930
DOI: 10.2147/ott.s201609